Iain L. O. Buxton Pharm.D.

Regents Professor, Foundation Professor and Chairman

Cellular and Molecular Pharmacology & Physiology | COBRE in Cell Biology | Department of Pharmacology

Iain Buxton

Contact Iain L. O. Buxton Pharm.D.


  • (775) 784-4800 
  • (775) 784-1566 lab (CMM)
  • (775) 784-4120 lab (CMM)



  • (775) 784-1620


Manville Health Sciences (MHS)
Room 1B

1664 North Virginia Street
Manville Health Sciences
RenoNV 89557
Iain Buxton


  • B.A., 1973, University of California, San Diego, Cell and Molecular Biology
  • Pharm.D., 1978, University of the Pacific


Receptor-signal transduction in cardiac and smooth muscle cells. Role of receptor-stimulated phosphoinositide metabolism; agonist-specific regulation of cyclic nucleotide action; role of adenyl purines in myometrial function and hormonal regulation of endothelial cell contractile factors.

The broad interests of our laboratory are those of receptor-signal transduction in mammalian systems. We approach our interests with modern biochemical and molecular methods that include intracellular imaging of events such as calcium release. One of our principal interests, for example, is the problem of premature delivery of babies. The signals that initiate contraction of the uterus at the time of labor are not known. We have recently described the contractile actions of adenyl purines on the smooth muscle of guinea pig uterus and find that the receptor that mediates the contraction of the tissue changes its coupling mechanism significantly during pregnancy in a fashion consistent with a role for these compounds in human parturition. The problem of premature delivery is a devastating human problem that takes its toll both in lives and dollars. We hope to contribute to an understanding of the onset of labor in order to help eliminate the problem of premature delivery.

Learn more on Dr. Buxton's lab page.

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