Iain L. O. Buxton D.Pharm.

Regents Professor, Foundation Professor and Chairman

Cellular and Molecular Pharmacology & Physiology | COBRE in Cell Biology | Department of Pharmacology

Iain Buxton

Contact Iain L. O. Buxton D.Pharm.

Phone

  • (775) 784-4800 
  • (775) 784-1566 lab (CMM)
  • (775) 784-4120 lab (CMM)

Email

Fax

  • (775) 784-1620

Location

Manville Health Sciences (MHS)
Room 1B

1664 North Virginia Street
Manville Health Sciences
RenoNV 89557

The University of Nevada School of Medicine is dedicated to protecting the privacy and security of your medical information. Please do not use email to communicate your personal health information to physicians or other patient care staff.

Iain Buxton

Education

  • B.A., 1973, University of California, San Diego, Cell and Molecular Biology
  • D.Pharm., 1978, University of the Pacific

Biography

Receptor-signal transduction in cardiac and smooth muscle cells. Role of receptor-stimulated phosphoinositide metabolism; agonist-specific regulation of cyclic nucleotide action; role of adenyl purines in myometrial function and hormonal regulation of endothelial cell contractile factors.

The broad interests of our laboratory are those of receptor-signal transduction in mammalian systems. We approach our interests with modern biochemical and molecular methods that include intracellular imaging of events such as calcium release. One of our principal interests, for example, is the problem of premature delivery of babies. The signals that initiate contraction of the uterus at the time of labor are not known. We have recently described the contractile actions of adenyl purines on the smooth muscle of guinea pig uterus and find that the receptor that mediates the contraction of the tissue changes its coupling mechanism significantly during pregnancy in a fashion consistent with a role for these compounds in human parturition. The problem of premature delivery is a devastating human problem that takes its toll both in lives and dollars. We hope to contribute to an understanding of the onset of labor in order to help eliminate the problem of premature delivery.

Subject experts database
for media

The subject experts database is an online index of University of Nevada School of Medicine doctors, educators, and professionals where media can easily find experts on a wide range of topics at the University of Nevada, School of Medicine.

  • Cancer
  • Cardiovascular Disease
  • Medications/Therapies
  • Pharmacology
  • Pre-Term Labor