Brian Perrino Ph.D.

Associate Professor

Cellular and Molecular Pharmacology & Physiology | Department of Physiology and Cell Biology

Brian Perrino

Contact Brian Perrino Ph.D.

Selected publications

2007

  • Kim, M., and Perrino, B.A.. . CaM kinase II activation and phospholamban phosphorylation by SNP in murine gastric antrum smooth muscles. Am J Physiol Gastrointest Liver Physiol. 292.g1045-54
  • Jabr, R.I., R.I., Wilson, A.J., Riddervold, M.H., Jenkins, A.H., Perrino, B.A., and Clapp. . Nuclear translocation of calcineurin Ab but not Aa by platelet-derived growth factor in rat aortic smooth muscle. Am. J. Physiol. Cell Physiol. 292:C2213-25

2006

  • Gary-Gouy, H., Sainz-Perez, A., Bismuth, G., Ghadiri, A., Perrino, B.A., and Dalloul, A. . Cyclosporin-A inhibits ERK phosphorylation in B cells by modulating the binding of Raf protein to Bcl2. BBRC 344:134-139
  • Hicks, G., Perrino, B.A., Marrion, N.V. . Inhibition of BKCa channel activity by association with calcineurin in rat brain. Eur. J. Neuroscience. 24:433-41
  • Kim, M., Han, I.S., Koh, S.D., and Perrino, B.A.. . Role of CaM kinase II and phospholamban in SNP-induced relaxation of murine gastric fundus smooth muscle. Am. J. Physiol. Cell Physiol. 291: C337-47

2005

  • Kim, M., Cho, S.Y., Han, I.S., Koh, S.D., and Perrino, B.A.. . CaM kinase II and phospholamban contribute to caffeine-induced relaxation of murine gastric fundus smooth muscle. Am. J. Physiol. Cell Physiol. 288:C1202-C1210
  • Leblanc, N., Ledoux, J., Saleh, S., Sanguinetti, A., Angermann, J., O’Driscoll, K., Britton, F., Perrino, B.A., and Greenwood, I.A.. . Regulation of Calcium-Activated Chloride Channels in Smooth Muscle Cells–A Complex Picture Is Emerging. Can. J. Physiol. Pharmacol. 83:541-546
  • Sergeant, G.P., Ohya, S., Rehill, J.R., Perrino, B.A., Koh, S.D., Sanders, K.M., and Horowitz, B.. . Regulation of Kv4.3 channels by Ca2+/calmodulin-dependent protein kinase II. Am. J. Physiol. Cell Physiol. 288:C304-C313

2004

  • Greenwood, I.A., Ledoux, J., Perrino, B.A., and Leblanc, N.. . Calcineurin-dependent dephosphorylation augments IClCa in pulmonary artery smooth muscle cells. J. Biol. Chem. 279:38830-38837

2002

  • Riddervold, M.H., Lorenz, J.M., Beckett, E.A.H., Baker, S.A., and Perrino, B.A.. . Differential autophosphorylation of Ca2+/calmodulin-dependent protein kinase II from phasic and tonic smooth muscle tissues. AJP Cell Physiol. 283: C1399-C1413
  • Perrino, B.A., Wilson, A.J., Ellison, P., and Clapp, L.H.. . Substrate selectivity and sensitivity to inhibition by immunophilin/immunosuppressant complexes of calcineurin heterodimers composed of the ? or ? catalytic subunit. Eur. J. Biochem. 269:3540-3548

2001

  • Martin, B.A.; Oxhorn, B.C.; Rossow, C.R.; and Perrino, B.A.. . A cluster of basic residues in calcineurin B participates in the binding of calcineurin to phosphatidylserine vesicles. J. Biochem. (Tokyo)129:843-849
  • Perrino, B.A. and Martin, B.A.. . Ca2+-and myristoylation-dependent association of calcineurin with phosphatidylserine. J. Biochem. (Tokyo)129:835-841
  • Amberg, G., Koh, S.D., Perrino, B.A., Hatton, W.J., and Sanders, K.M.. . Regulation of A-type potassium channels in murine colonic myocytes by phosphatase activity. Am. J. Physiol. Cell Physiol. 281:C2020-2028

2000

  • Perrino, B.A.. . Regulation of calcineurin-dependent signaling pathways by protein targeting. Recent Research Developments in Endocrinology. 1:209-232

1999

  • Koh, S. D.; Perrino, B. A.; Hatton, W. J.; Kenyon, J. L.; and Sanders, K. M.. . Novel regulation of the A-type current in murine proximal colon by calcium/calmodulin-dependent protein kinase II. J. Physiol. 517 (Part1):75-84
  • Perrino, B.A.. . Regulation of calcineurin phosphatase activity by its autoinhibitory domain. Arch. Biochem. Biophys. 372:159-165

1998

  • Perrino, B.A. and Soderling, T.R.. . Biochemistry and Pharmacology of the Calmodulin-Regulated Phosphatase Calcineurin. Invited chapter for “Calmodulin and Signal Transduction”, Academic Press, Eds: Linda van Eldik and D. Martin Watterson. 169-236

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