Brian Perrino Ph.D.

Associate Professor

Cellular and Molecular Pharmacology & Physiology | Department of Physiology and Cell Biology

Brian Perrino

Contact Brian Perrino Ph.D.

Selected publications


  • Kim, M., and Perrino, B.A.. . CaM kinase II activation and phospholamban phosphorylation by SNP in murine gastric antrum smooth muscles. Am J Physiol Gastrointest Liver Physiol. 292.g1045-54
  • Jabr, R.I., R.I., Wilson, A.J., Riddervold, M.H., Jenkins, A.H., Perrino, B.A., and Clapp. . Nuclear translocation of calcineurin Ab but not Aa by platelet-derived growth factor in rat aortic smooth muscle. Am. J. Physiol. Cell Physiol. 292:C2213-25


  • Gary-Gouy, H., Sainz-Perez, A., Bismuth, G., Ghadiri, A., Perrino, B.A., and Dalloul, A. . Cyclosporin-A inhibits ERK phosphorylation in B cells by modulating the binding of Raf protein to Bcl2. BBRC 344:134-139
  • Hicks, G., Perrino, B.A., Marrion, N.V. . Inhibition of BKCa channel activity by association with calcineurin in rat brain. Eur. J. Neuroscience. 24:433-41
  • Kim, M., Han, I.S., Koh, S.D., and Perrino, B.A.. . Role of CaM kinase II and phospholamban in SNP-induced relaxation of murine gastric fundus smooth muscle. Am. J. Physiol. Cell Physiol. 291: C337-47


  • Kim, M., Cho, S.Y., Han, I.S., Koh, S.D., and Perrino, B.A.. . CaM kinase II and phospholamban contribute to caffeine-induced relaxation of murine gastric fundus smooth muscle. Am. J. Physiol. Cell Physiol. 288:C1202-C1210
  • Leblanc, N., Ledoux, J., Saleh, S., Sanguinetti, A., Angermann, J., O’Driscoll, K., Britton, F., Perrino, B.A., and Greenwood, I.A.. . Regulation of Calcium-Activated Chloride Channels in Smooth Muscle Cells–A Complex Picture Is Emerging. Can. J. Physiol. Pharmacol. 83:541-546
  • Sergeant, G.P., Ohya, S., Rehill, J.R., Perrino, B.A., Koh, S.D., Sanders, K.M., and Horowitz, B.. . Regulation of Kv4.3 channels by Ca2+/calmodulin-dependent protein kinase II. Am. J. Physiol. Cell Physiol. 288:C304-C313


  • Greenwood, I.A., Ledoux, J., Perrino, B.A., and Leblanc, N.. . Calcineurin-dependent dephosphorylation augments IClCa in pulmonary artery smooth muscle cells. J. Biol. Chem. 279:38830-38837


  • Riddervold, M.H., Lorenz, J.M., Beckett, E.A.H., Baker, S.A., and Perrino, B.A.. . Differential autophosphorylation of Ca2+/calmodulin-dependent protein kinase II from phasic and tonic smooth muscle tissues. AJP Cell Physiol. 283: C1399-C1413
  • Perrino, B.A., Wilson, A.J., Ellison, P., and Clapp, L.H.. . Substrate selectivity and sensitivity to inhibition by immunophilin/immunosuppressant complexes of calcineurin heterodimers composed of the ? or ? catalytic subunit. Eur. J. Biochem. 269:3540-3548


  • Martin, B.A.; Oxhorn, B.C.; Rossow, C.R.; and Perrino, B.A.. . A cluster of basic residues in calcineurin B participates in the binding of calcineurin to phosphatidylserine vesicles. J. Biochem. (Tokyo)129:843-849
  • Perrino, B.A. and Martin, B.A.. . Ca2+-and myristoylation-dependent association of calcineurin with phosphatidylserine. J. Biochem. (Tokyo)129:835-841
  • Amberg, G., Koh, S.D., Perrino, B.A., Hatton, W.J., and Sanders, K.M.. . Regulation of A-type potassium channels in murine colonic myocytes by phosphatase activity. Am. J. Physiol. Cell Physiol. 281:C2020-2028


  • Perrino, B.A.. . Regulation of calcineurin-dependent signaling pathways by protein targeting. Recent Research Developments in Endocrinology. 1:209-232


  • Koh, S. D.; Perrino, B. A.; Hatton, W. J.; Kenyon, J. L.; and Sanders, K. M.. . Novel regulation of the A-type current in murine proximal colon by calcium/calmodulin-dependent protein kinase II. J. Physiol. 517 (Part1):75-84
  • Perrino, B.A.. . Regulation of calcineurin phosphatase activity by its autoinhibitory domain. Arch. Biochem. Biophys. 372:159-165


  • Perrino, B.A. and Soderling, T.R.. . Biochemistry and Pharmacology of the Calmodulin-Regulated Phosphatase Calcineurin. Invited chapter for “Calmodulin and Signal Transduction”, Academic Press, Eds: Linda van Eldik and D. Martin Watterson. 169-236

Subject experts database
for media

The subject experts database is an online index of University of Nevada School of Medicine doctors, educators, and professionals where media can easily find experts on a wide range of topics at the University of Nevada, School of Medicine.

  • Gastrointestinal